Looking to play the more melee-focused castes without having to click through my abilities like a baldo. Thanks in advance 
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Prime Queen here. Still mouse click my abilities
ERF, because they are close to WASD, and C for anything extra. alt for tailstab.
For me I find c,v,g,b bound to my 1st, 2nd, 3rd, and 4th abilities works the best. Having your abilities right next to your movement keys helps a lot imo. F for tail stab, shift+f for queen screech. Space+shift to hide.
ZCV, F for tailstab, R for some obscure ability that I only use to open queen build menu or burrower stomp, and I still manually click screech just cause it’s funny.
You could also probably use spacebar for something, it’s pretty useful
c(1st), v(2nd), g(3rd), b(4th) + n is tail stab are mine too I click for Screech & Switch Spit type. I click for a bunch of different abilities since some xenos have more than four.
Ability 1,2,3,4 are respectivly numb 3, numb 4, numb 1, numb 2 (I use a logitech 522 with its 4 side buttons).
And c for tailstab. The rest I don’t have hotkeyed.
1,2,3,4,5 - abilities
F - tailstab
CVNG - help, disarm, grab, harm
Shift+R - rest
B - resist
Shift+1,2,3 pheromones
F for healing/leaping/charging/dash/changes per caste. Usually the most important ability.
ZXCV for The rest of abilities.
Spacebar for tail stab, I don’t know why people don’t use this one. It’s not like you use spacebar as xeno. You don’t get attachies.
G to rest.
H to roll. (This is separate and far away because I see too many people rolling early and getting stunned/killed. It’s always a decision when to roll.)
Q stays at switch hands because if you have to master tackle/drag fu, it’s needed.
1-2-3-4 for intents, for the tackle fu above and to learn to drag fu.
Z tail stab, c pounce, space bone spur, V zoom, fg no clue what they do but I press them in the hopes they do something when I’m not playing runner, R for screech
Z, X, V, C - abilities 1-4
E - Tailstab
Q - Evolve
8, 9, 0 - pheromones
QER, 1st 2nd 3rd abilities, ~ (key under ESC) for tailstab, other abilities I just use the mouse for (though I noticed for vamp lurker being able to headbite fast is pretty important)
You’re gonna hate this, but I highly recommend a Razer Naga or some other mouse with a numpad on the thumb. I find it incredibly useful for hotkeying for both marine and xeno, where I have all my inventory binds and xeno abilities set for 5 through =. I have body targeting set to ctrl+1-9 with ctrl+1 and Ctrl+3 cycling in different directions, which is excellent for corpsman/doctor.
I do keep tailstab on V though (I am using majority Goonstation binds for basic controls).
R, F, C, and G for abilities. You should just use whatever keys are close to your movement options.